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Granuloma Riga-Fede (eosinophile traumatic ulcerative granuloma): A variant of a monoclonal CD30+ lymphoproliferative disorder

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Author(s): Kuhl Sebastian | Schulze Ralf | Hansen Torsten | Muller-Hermelink Hans | Hans-Ullrich Volker

Journal: Journal of Oral and Maxillofacial Pathology
ISSN 0973-029X

Volume: 12;
Issue: 1;
Start page: 34;
Date: 2008;
Original page

Keywords: Clonality | eosinophilia | granuloma Riga-Fede | traumatic | ulceration

ABSTRACT
The granuloma Riga-Fede (GRF) belongs to benign self-healing ulcerative lesions, usually located in the oral mucosa. Histological characteristics are eosinophilia accompanied by a population of large mononuclear cells, leading to synonyms as eosinophilic ulcer of the oral mucosa, traumatic eosinophilic granuloma, or traumatic ulcerative granuloma with stromal eosinophilia. Its rare appearance and clinical similarity to squamous cell carcinoma cause difficulties in diagnosis and can lead to severe overtreatment. Recent publications have revealed that GRF could be included within the spectrum of CD30+ lymphoproliferative disorders due to the positivity of CD30 antigen in some reported cases. We present a case of a 19-year-old patient with GRF localized in the attached gingiva of the upper left first molar with CD30 antigen positivity and monoclonal T cell receptor-gamma (TCR-g) gene rearrangement. It is suggested that GRF can represent a subset of CD30+ lymphoproliferative disorders.

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