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Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines

Author(s): Morsy Ahmed El-Apasery | Saleh Mohamed Al-Mousawi | Mohamed Helmy Elnagdi

Journal: European Journal of Chemistry
ISSN 2153-2249

Volume: 2;
Issue: 2;
Start page: 168;
Date: 2011;
Original page

Keywords: Enaminone | Solvent-free | Green chemistry | Dye intermediates | Microwave irradiation | 1 | 3 | 5-trisubstituted benzenes

Enaminones were obtained in good yields via condensing methyl ketones with (N,N-dimethylformamide dimethyl acetal) DMF-DMA under microwave irradiation in absence of solvent. These enaminones were readily converted into 1,3,5-trisubstituted benzenes. Reacting enaminones in presence of ammonium acetate has afforded pyridine derivatives.
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