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Has asialoglycoprotein receptor (ASGP-R) a role to play in binding and processing of different parasites?

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Author(s): Baričević Ivona I. | Čuperlović Margita | Sofronić-Milosavljević Ljiljana Đ. | Vićovac-Panić Ljiljana M.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 52;
Issue: 5-6;
Start page: 361;
Date: 2002;
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Keywords: asialoglycoprotein receptor (ASGP-R) | Echinococcus granulosus | oligosaccharide ligand | Trichinella spiralis

ABSTRACT
Liver asialoglycoprotein receptor (ASGP-R), which specifically recognizes and binds galactose and N-acetyl galactosamine, has been implicated in binding and endocytosis of glycoproteins. Therefore, the possibility that it may have a role in contacting and processing pathogenic organisms was investigated. The interaction in vitro between ASGP-R and surface oligosaccharide structures of Echinococcus granulosus and Trichinella spiralis was studied by immunohistochemical methods. Specific binding of ASGP-R to ligands on the surface protoscolex of E. granulosus was demonstrated. To the contrary, ASGP-R bound ligand(s) of T. spiralis stihocytes, while a staining reaction was absent from the parasite cuticle. These results show that ASGP-R could take part in binding to and retention of E. granulosus in liver cells, thus contributing to its hepatotropic activity.
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