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Hashimoto encephalopathy: Neurological and psychiatric perspective

Author(s): Pavlović D.M. | Pavlović Aleksandra M. | Lačković Maja

Journal: Archives of Biological Sciences
ISSN 0354-4664

Volume: 61;
Issue: 3;
Start page: 383;
Date: 2009;
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Keywords: Hashimoto encephalopathy | antithyroid antibodies | corticosteroid therapy | neuropsychiatric manifestations

Hashimoto encephalopathy (HE) is an autoimmune disease with neurological and neuropsychiatric manifestations and elevated titers of antithyroid antibodies in serum and cerebrospinal fluid. Patients are mostly women. Age varies from 8 to 86 years. Prevalence of HE is estimated to be 2.1/100,000. Neurological and/or psychiatric symptoms and signs constitute the clinical picture. The disease responds well to corticosteroid therapy, but sometimes other immunomodulatory therapies must be applied. Autoimmune mechanisms with antibodies against antigens in the brain cortex are suspected. The course of the disease can be acute, subacute, chronic, or relapsing/remitting. Some patients improve spontaneously, but a few died in spite of adequate therapy.
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