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Hashimoto thyroiditis in children and adolescents: evaluation of clinical and laboratory findings

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Author(s): Bumin | Aslıhan | Özlem | Nihal

Journal: Turk Pediatri Arşivi
ISSN 1306-0015

Volume: 46;
Issue: 4;
Start page: 318;
Date: 2011;
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Keywords: Adolescent | child | Hashimoto | thyroiditis

ABSTRACT
Aim: The objective of this study was retrospective analyses of clinical and laboratory findings of children and adolescents with Hashimoto thyroiditis. Material and Method: We evaluated 78 patients with HT who were between 4-17 years of age. Physical examination and family history of the patients, thyroid functions, auto-antibody titers and USG scans were evaluated retrospectively. Results: Two (2.6%) patients presented with hyperthyroidism, while 10 (11.7%), 17 (21.8%) and 49 (62.8%) patients with hypothyroidism, subclinical hypothyroidism and euthyroidism, respectively. The major symptoms were nervousness, sweating, weight gain and loss of appetite. Sixty-three (80.8%) patients had goiter and 52 (66.7%) patients had positive anti-thyroid peroxidase antibody at diagnosis. Among the 19 patients who were eutyroid initially two patients became hyperthyroid, one became hypothyroid and one became subclinical hypothyroid during follow-up. Family history for thyroid disease was determined in 31 (39%) patients.Conclusions: Clinical and laboratory findings may vary at diagnosis and during follow-up in children and adolescents with HT. Periodic monitoring of the patients is very important. (Turk Arch Ped 2011; 46: 318-22)

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