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HBsAg Variants: Common Escape Issues

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Author(s): Payam Dindoost | Seyed Mohammad Jazayeri | Hadi Karimzadeh | Seyed Mohammad Miri | Seyed Moayed Alavian

Journal: Jundishapur Journal of Microbiology
ISSN 2008-3645

Volume: 5;
Issue: 4;
Start page: 521;
Date: 2012;
Original page

Keywords: HBSAg | Escape Mutant | Blood Donor | Iran

ABSTRACT
Abstract: Mutations have been described in all of the four open reading frames of the hepatitis B virus (HBV), however, from a clinical perspective the surface escape mutant is the most troublesome. Hepatitis B surface antigen (HBsAg) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. HBV mutants with amino acid substitutions, within the common “a” determinant of HBsAg have been identified, and as a result, the HBsAg cannot be detected in some assays (diagnostic-escape). In these situations, the HBsAg mutants may arise in patients with a HBV infection, but they have been diagnosed as HBsAg negative. This review deals with the latest results on the performance of HBsAg assays, as well as the reactivity of native and or recombinant mutants of HBsAg.
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