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Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

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Author(s): Adriano M Pellicelli | Massimo Marignani | Valerio Zoli | Mario Romano | Aldo Morrone | Lorenzo Nosotti | Giuseppe Barbaro | Antonio Picardi | Umberto Vespasiani Gentilucci | Daniele Remotti | Cecilia D'Ambrosio | Caterina Furlan | Fabrizio Mecenate | Ettore Mazzoni | Ignazio Majolino | Roberto Villani | Arnaldo Andreoli | Giorgio Barbarini

Journal: World Journal of Hepatology
ISSN 1948-5182

Volume: 3;
Issue: 11;
Start page: 278;
Date: 2011;
Original page

Keywords: Hepatitis C virus infection | Diffuse large B cell lymphoma | Indolent lymphoma | Pegylated interferon | Lymphomagenesis

ABSTRACT
AIM: To evaluate if indolent B cell-non Hodgkin’s lymphoma (B-NHL) and diffuse large B-cell lymphoma (DLBCL) in hepatitis C virus (HCV) positive patients could have different biological and clinical characteristics requiring different management strategies. METHODS: A group of 24 HCV related B-NHL patients (11 indolent, 13 DLBCL) in whom the biological and clinical characteristics were described and confronted. Patients with DLBCL were managed with the standard of care of treatment. Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed. The outcomes of the different approaches were compared. RESULTS: Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype. Five of the 9 patients with indolent HCV-related B-NHL treated with only antiviral therapy, achieved a complete response of their onco-haematological disease (55%). Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response (54%). CONCLUSION: HCV genotypes and duration of HCV infection differed between B-NHL subtypes. Indolent lymphomas can be managed with antiviral treatment, while DLBCL is not affected by the HCV infection.
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