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Hepatitis C Virus Assembly Imaging

Author(s): Costin-Ioan Popescu | Yves Rouillé | Jean Dubuisson

Journal: Viruses
ISSN 1999-4915

Volume: 3;
Issue: 11;
Start page: 2238;
Date: 2011;
Original page

Keywords: hepatitis C virus | virus assembly | cellular imaging

Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified the lipid droplets (LDs) as the potential viral assembly site. Here, we aim to review the mechanisms that govern the viral proteins recruitment to LDs and discuss the current model of HCV assembly process. Based on previous examples, this review will also discuss advanced imaging techniques as potential means to extend our present knowledge of HCV assembly process.
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