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Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance

Author(s): Parvaiz Fahed | Manzoor Sobia | Tariq Huma | Javed Farakh | Fatima Kaneez | Qadri Ishtiaq

Journal: Virology Journal
ISSN 1743-422X

Volume: 8;
Issue: 1;
Start page: 474;
Date: 2011;
Original page

Keywords: HCV Infection | Molecular Pathways | Insulin Resistance

Abstract Chronic Hepatitis C virus has the potential of inducing insulin resistance and type 2 Diabetes Mellitus in vitro as well as in vivo . Structural and non-structural proteins of HCV modulate cellular gene expression in such a way that insulin signaling is hampered, concomitantly leads toward diabetes mellitus. A number of mechanisms have been proposed in regard to the HCV induced insulin resistance involving the upregulation of Inflammatory cytokine TNF-α, hypophosphorylation of IRS-1 and IRS-2, phosphorylation of Akt, up-regulation of gluconeogenic genes, accumulation of lipids and targeting lipid storage organelles. This review provides an insight of molecular mechanisms by which HCV structural and non-structural proteins can induce insulin resistance.
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