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Hepatoprotective activity of Azima tetracantha Lam. in experimental animals

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Author(s): T. Nargis Begum a*, M. H. Muhammad Ilyas b and A. Vijaya Anand c

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 7;
Start page: 2359;
Date: 2011;
Original page

Keywords: Hepatoprotective activity | Azima tetracantha | Carbon tetrachloride | Silymarin.

ABSTRACT
In the present study, the ethanolic leaf extract of Azima tetracantha Lam (A. tetracantha) was investigated for hepatoprotective activity in wistar albino rats using CCl4 induced hepatotoxicity. Rats weighing (180 – 230 gm) were taken for the experiment, divided into four groups of six animals each. CCl4 (1ml/kg) was administered to groups of animals by subcutaneous injection. Group I served as control, receiving normal saline only (10 ml/kg i.p.) Group 2 and Group 3 received ethanolic leaf extract of A. tetracantha in two divided doses (100 mg/kg and 200 mg/kg i.p) and the reference drug silymarin (25mg/kg i.p) was administered to group 4 respectively daily once for 15 days after CCl4 administration. All the animals were sacrificed at the end of 15th day after CCl4 administration, blood was drawn from the carotid artery and serum was separated for the different assays. All data were analyzed with student‘t’ test. A maximum hepatoprotective activity was found to be 200 mg/kg leaf extract treated group which was compared with standard drug silymarin (25 mg/kg), histopathological studies were also performed.
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