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Hepatoprotective Activity of Bi-Herbal Ethanolic Extract on CCl4 Induced Hepatic Damage in Rats

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Author(s): P. Samudram | H. Rajeshwari | R. Vasuki | A. Geetha | P. Sathiya Moorthi

Journal: Asian Journal of Biochemistry
ISSN 1815-9923

Volume: 3;
Issue: 5;
Start page: 308;
Date: 2008;
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Keywords: Hepatoprotective | marker enzymes | bi-herbal ethanolic extract | carbon tetra chloride

ABSTRACT
4) induced hepatic damage in rats was investigated. Ethanolic extract from the leaves of Melia azedarach and seeds of Piper longum at a dose level of 50 mg kg-1 body weight was administered orally daily once for 14 days, prior to the administration of 0.2 mL of CCl4 kg-1 body weight for 7 days. The substantially elevated serum marker enzymes such as Serum glutamic Oxaloacetic Transaminase (SGOT), Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lactatedehydrogenase (LDH), Gamma glutamyl Transferase (γGT) and 5 Nucleotidase (5NT), due to CCl4 treatment were restored towards normalization in rats pretreated with BHEE. The determination of liver weight and biochemical parameters such as serum bilirubin and blood urea showed a remarkable decrease in rats pre- treated with the BHEE when compared with those administered CCl4 alone. In addition BHEE significantly increased the total protein, total cholesterol and triglyceride also towards normal levels. Silymarin at a dose level of 50 mg kg-1 was used as a standard reference also exhibited significant hepatoprotective activity against CCl4 induced hepatotoxicity. The results of this study strongly indicate that BHEE has got a potent hepatoprotective action against CCl4 induced hepatic damage in rats.]]>
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