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Hepatoprotective Activity of Methanol Extract of Tecomella undulata against Alcohol and Paracetamol Induced Hepatotoxicity in Rats

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Author(s): D Singh

Journal: Life Sciences and Medicine Research
ISSN 1948-7886

Volume: 2011;
Start page: LSMR-26;
Date: 2011;
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Keywords: Liver damage | antioxidants | Tecomella undulate | hepatoprotection

ABSTRACT
Plant products play a crucial role in the hepatoprotection through its antioxidants property. Therefore, search for modern medicine of plant origin with this property has become a central focus on hepatoprotection today. This study investigated to search a new hepatoprotective agent from natural sources, the methanol extract of folk medicinal plant, T. undulata leaves was tested against liver damage of albino rats. Levels of serum marker enzymes i.e. AST, ALT (aminotransferases), ALP (alkaline phosphatase), GGT (gamma glutamyl transpeptidase) and total bilirubin in serum alongwith the activities of LPO (lipid peroxidation), SOD (superoxide dismutase), CAT (catalase), GSH (reduced glutathione) and GPx (glutathione peroxidase) in liver homogenate from treated rats were monitored, respectively. The histopathological changes of liver sections were also compared with the respective controls. 30% alcohol and paracetamol induced significant (P
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