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HEPATOPROTECTIVE ACTIVITY OF SESAME MEAL ON HIGH FAT FED WISTAR RATS

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Author(s): Anitha Uthandi | Karuppasamy Ramasamy

Journal: International Journal of Pharma Sciences and Research
ISSN 0975-9492

Volume: 2;
Issue: 12;
Start page: 205;
Date: 2011;
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Keywords: Sesame meal | high fat diet | wistar rat | pioglitazone. hepatoprotective.

ABSTRACT
Sesamum indicum have been widely used in tradition medicine for thousand of year, it improves liver functions and provides protection against high fat fed metabolic rats. Present investigations were carried out on the hepatoprotective role of sesame meal treatment to high fat fed wistar rat. Healthy adult male wistar rats were divided into five groups. Group I: rats were fed a standard laboratory diet (20g/rat/day), Group II: rats were fed a high-fat diet alone (20mg/rat/day), Group III: rats were fed with combined mixture of 70% of high-fat diet with 30% sesame meal (20mg/rat/day), Group IV: rats were fed a high fat diet was administered with pioglitazone (25mg/kg of body weight) via intravenous in each day, Group V: rats were fed combined mixture of 70% standard laboratory pellet and 30% sesame meal (20mg/rat/day). The rats were sacrificed at the end of the experimental (thirteen week) period. High fat fed rat registered significantly increase in body weight and liver weight at the end of experimental period. The high fat fed rat substantially elevated its serum and liver tissue AST, ALT, ALP, bilirubin with decreased in total protein levels. Whereas the levels of all parameterssignificantly restored towards normalization by the sesame meal treatment. The results obtained suggest that the sesame meal have potent hepatoprotective action on high fat fed rats. A comparison of the performance in both sesame meal and pioglitazone treatment on high fat fed rat in respect of hepato-protective role is clearly indicate that the sesame meal treatment was more or less very equal to the result of pioglitazone as well as to the normal level.
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Tango Jona
Tangokurs Rapperswil-Jona