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Hepatoprotective Effect of Aqueous Acetone Extract of Sida alba L. (Malvaceae) Against Alcohol Induced Liver Damage in albinos Wistar Rats

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Author(s): K. Konaté | A. Souza | R.R.R. Aworet Samseny | B. Batchelili | B. Marlaine | M. Lamidi | N. Barro | J. Millogo-Rasolodimby | O.G. Nacoulma

Journal: British Journal of Pharmacology and Toxicology
ISSN 2044-2459

Volume: 2;
Issue: 1;
Start page: 37;
Date: 2011;
Original page

Keywords: Albinos Wistar rats | biochemical parameters | hepatoprotective potential | Sida alba

ABSTRACT
The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract of Sida alba. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally hepatics affections in albinos Wistar rats. Animals were treated by gavage during 28 days with different doses of aqueous acetone extracts of Sida alba. (75, 100, 150 mg/kg) suspended in 35% ethanol. Control groups received alcohol 35% and water. In vivo administration of 35% ethano l for 28 days results an activity of liver marker enzymes (AST, ALT, ALP), glucose, triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum as compared with rats which received water (control water). However, administrations of 35% ethanol along with aqueous acetone extract decreased the activities of liver markers enzyme in serum comparatively to the control water group (p
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