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HEPATOPROTECTIVE EFFECT OF EUPHORBIA THYMIFOLIA WHOLE PLANT EXTRACT ON CCl4 INDUCED HEPATIC DAMAGE IN RATS

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Author(s): Syed Aamir | Tippeswamy B S | Kulkarni V H | Hegde Karunakar

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 2;
Start page: 681;
Date: 2011;
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Keywords: Antioxidants | Carbon tetrachloride | Euphorbia thymifolia | Hepatoprotective activity.

ABSTRACT
The present study has been designed to evaluate the hepatoprotective and in-vivo antioxidant activity of ethanolic extract of the whole plant of Euphorbia thymifolia (EEET) against carbon tetrachloride (CCl4) - induced hepatotoxicity in experimental rats. The levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), uric acid, total protein and total bilirubin were determined. Antioxidant status in liver was determined by measuring the activity of malondialdehyde (MDA), glutathione (GSH) and catalase (CAT). Total wet weight and histopathological study of isolated liver specimen was also carried out. The oral pre-treatment with EEET (100, 200 mg/kg) showed significant hepatoprotection against CCl4 induced hepatotoxicity by decreasing the activities of serum marker enzymes, bilirubin and lipid peroxidation, and significant increase in the levels of uric acid, GSH, CAT and protein in a dose dependent manner, which was confirmed by the histopathological examinations. Data also showed that EEET possessed strong antioxidant activity, which may probably leads to the promising hepatoprotective activities of Euphorbia thymifolia whole plant extract.
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