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Hepatoprotective effect of Momordica charantia in ammonium chloride induced hyperammonemic rats

Author(s): A. Justin Thenmozhi and P. Subramanian*

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 3;
Start page: 700;
Date: 2011;
Original page

Keywords: Momordica charantia | ammonia | antioxidants | oxidative stress | hyperammonemia | lipid peroxidation.

Momordica charantia, is an indigenous plant used in Ayurvedic medicine in India. Our aim is to investigate the effect of M. charantia fruit extract on circulatory liver markers, lipid peroxidation and antioxidants status in ammonium chloride (AC) induced hyperammonemic rats. Male albino Wistar rats (180-200 g) were used for the study. Hyperammonemia was induced by interaperitonial injection (i.p) of AC (100 mg/kg body weight). Rats were treated with M. charantia fruit extract (300 mg/kg body weight) via oral administration. Administration of M. charantia fruit extract in hyperammonemic rats reduced the levels of ammonia and urea. The antioxidant property M. charantia fruit extract was studied by assessing the activities of thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP) and liver markers (alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and the levels of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), vitamins A, C and E in AC treated rats. Oxidative stress was effectively modulated by M.charantia fruit extract administration. M. charantia fruit extract significantly improved the status of antioxidants and decreased ammonia, urea, lipid peroxidation and liver markers enzymes as compared to AC treated group. However examination of the efficacy of the active constituents of the M. charantia on hyperammonemia is desirable.
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