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The Hepatoprotective Effect of The Polyphenolic Compounds in the Roots of Trichilia connaroides Wight and Arn

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Author(s): Garima Agarwal*, Anil Kumar Pant | Subroto Kumar Hore

Journal: Hygeia : Journal for Drugs and Medicines
ISSN 0975-6221

Volume: 2;
Issue: 2;
Start page: 22;
Date: 2010;
Original page

Keywords: Trichilia connaroides | Carbon tetrachloride | Hepatoprotective activity | Antioxidant activity | Histopathology.

ABSTRACT
Trichilia species are used in the treatment of liver disorders and as a tonic in the traditional medicine. The present study was designed to evaluate the hepatoprotective effects of aqueous extract of T. connaroides roots on carbon tetrachloride induced hepatotoxicity in comparision with the known hepatoprotective agent Liv-52. Carbon tetrachloride induced changes in serum enzymatic levels of aspartate amino transferase , alanine amino transferase , alkaline phosphatase and total protein were restored towards normal levels by the extract. The biochemical observations were supported by the histopathological examination of rat liver sections. The results indicate that the extract offers hepatoprotection in a dose-dependent manner. The effect was comparable to that produced by Liv-52. Simultaneously, in-vitro anti-oxidant activity of the extract as evaluated in terms of reducing power, radical scavenging activity and chelating activity on Fe+2 also support its hepatoprotective action. Phytochemical examination of the extract revealed the presence of antioxidant phenolics.
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