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Hepatoprotective Effects of African Locust Bean (Parkia clappertoniana) and Negro Pepper (Xylopia aethiopica) in CCl4-Induced Liver Damage in Wistar Albino Rats

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Author(s): K.C. Patrick- Iwuanyanwu | M.O. Wegwu | J.K. Okiyi

Journal: International Journal of Pharmacology
ISSN 1811-7775

Volume: 6;
Issue: 5;
Start page: 744;
Date: 2010;
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Keywords: hepatic injury | carbon tetrachloride | African locust bean | lipid peroxidation | negro pepper

ABSTRACT
The aim of this study was to evaluate the protective effects of Negro pepper (Xylopias aethiopica) and African locust bean (Parkia clappertoniana) against carbon tetrachloride (CCl4) -induced hepatotoxicity in rats. Carbon tetrachloride (0.5 mL kg-1 b.wt.) was administered after 21 days of feeding animals with diets containing Negro pepper (X. aethiopica) and African locust bean (P. clappertoniana). Serum alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) levels 24 h after CCl4 administration decreased significantly (p≤0.05) in rats pre-treated with X. aethiopica and P. clappertoniana than in CCl4 -treated rats only. Total serum bilirubin also showed a remarkable decrease in rats pre-treated with X. aethiopica and P. clappertoniana when compared to those administered CCl4 alone. Lipid peroxidation expressed by malondialdehyde (MDA) concentration was significantly decreased (p≤0.05) in rats pre-treated with X. aethiopica and P. clappertoniana than in rats administered CCl4 alone. Histopathological examinations of rats administered CCl4 alone revealed severe hepatic damage to the liver. However, rats pre-treated with X. aethiopica and P. clappertoniana showed significant improvements in the architecture of rat liver. These findings suggest that X. aethiopica and P. clappertoniana may be protective against CCl4- induced liver damage in rats.
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