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Hepatoprotective effects of Cynara scolymus L. extract on CCl4 induced liver injury in broiler chickens

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Author(s): Nateghi R. et al.

Journal: International Journal of AgriScience
ISSN 2228-6322

Volume: 3;
Issue: 9;
Start page: 678;
Date: 2013;
Original page

Keywords: CCl4 | Cynara scolymus L. | hepatoprotection | broilers

ABSTRACT
An investigation was done on to evaluate the effect of Cynara scolymus L. (artichoke) on protection against carbon tetrachloride (CCl4) induced hepatotoxicity in broiler chickens. Tests for liver injury were done on broiler chicks arranged in to four experimental groups, each containing 10 chicks (Ross, 308); no artichoke aqueous extract (control group), 0.5g/kg/day of artichoke aqueous extract (AE group), 1ml/kg/bwt of CCl4 (CCl4 group), and 0.5g/kg/bwt of artichoke aqueous extract plus 1ml/kg/bwt of CCl4 (AE+ CCl4 group). Blood samples were analyzed for the liver enzymes; Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and alkaline phosphates (ALP). Liver samples were processed for histological evaluations. The aqueous extract of Cynara scolymus L. at a dose of 0.5g/kg body weight exhibited a moderate hepatoprotective effect by reducing levels of AST (P
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