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Hepatotherapeutic Effect of Aloe Vera in Alcohol-induced Hepatic Damage

Author(s): W.A. Saka | R.E. Akhigbe | O.S. Ishola | E.A. Ashamu | O.T. Olayemi | G.E. Adeleke

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 14;
Issue: 14;
Start page: 742;
Date: 2011;
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Keywords: Aloe vera | alcohol | liver | transaminase | phosphatase | bilirubin

There is a lack of reliable hepatotherapeutic drugs in modern medicine in the management of alcohol/drug-induced liver damage. Aloe vera extract has been used in folklore medicine for its medicinal values. This study evaluates the hepatotherapeutic activity of aqueous extract of Aloe vera gel in rats. Sprague-Dawley rats were divided into three groups; the negative control, positive control and the extract-treated groups. The negative control received only distilled water daily. The positive control received alcohol, while the extract-treated group received aqueous extract of Aloe vera and alcohol. Hepatotoxicity was induced in the positive control and extract-treated rats with alcohol. The hepatotherapeutic effect was evaluated by performing an assay of the serum total bilirubin, alkaline phosphatase, aspartate and alanine transaminases and liver histopathology. Alanine transaminase activities were comparable in all groups. Alcohol treatment alone significantly (p
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