Academic Journals Database
Disseminating quality controlled scientific knowledge

Hepatotoxicity of dinitro-O-cresol in rats (Rattus norvegicus)

Author(s): Dere Egemen | Ozdikicioglu Ferda | Tosunoglu H.

Journal: Acta Veterinaria
ISSN 0567-8315

Volume: 57;
Issue: 5-6;
Start page: 497;
Date: 2007;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: DNOC | rat | LDH | AST | ALT | ALP

In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8th hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats.
Save time & money - Smart Internet Solutions      Why do you need a reservation system?