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Hepatotoxicity and nephrotoxicity evaluation in Wistar albino rats exposed to Morinda lucida leaf extract

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Author(s): Taofeeq Oduola | Ibrahim Bello | Ganiyu Adeosun | Abdul-Waheed Ademosun | Gassal Raheem | Godwin Avwioro

Journal: North American Journal of Medical Sciences
ISSN 1947-2714

Volume: 2;
Issue: 5;
Start page: 230;
Date: 2010;
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Keywords: Morinda lucida | leaf extract | liver | kidney | toxicity | rats

ABSTRACT
Background: Aqueous extract of Morinda lucida benth leaf is consumed in Southern Nigeria in the treatment of malaria without any regard for its safety. Aim: The aim of the study was to investigate the effects of ingestion of the ethanolic leaf extract of the plant on liver and kidney functions in Wistar albino rats. Materials and Methods: Acute oral toxicity test was performed to determine the LD50; sub-chronic toxicity study was then carried out by oral administration of different doses of the extract on daily basis to different groups of rats for 42 days. The animals were subsequently sacrificed, and liver and kidney functions assessed biochemically using standard techniques. Results: The acute oral toxicity result, LD50, revealed Morinda lucida leaf extract to be non-lethal at 6400mg/kg body weight. The results obtained for liver and kidney function parameters indicated that ingestion of Morinda lucida leaf extract has no toxic effect on liver and kidney functions. Conclusion: The results can form the basis for clinical trials in humans.
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