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HER 2-NEU PROTIEN EXPRESSION IN BREAST CANCER STUDY BY IMMUNOHISTOCHEMISTRY(IHC) METHOD

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Author(s): Rajesh M. Patel

Journal: International Journal of Pharmaceutical Research and Development
ISSN 0974-9446

Volume: 2;
Issue: 7;
Start page: 10;
Date: 2010;
Original page

Keywords: Breast cancer | HER 2-neu protein | tumorigenesis | Immunohistochemistry method | IHC

ABSTRACT
Growth factor and their receptors are paying promising roles in cell development, growth and differentiation. Many receptor posses intrinsic tyrosine kinase activity that is activated upon the receptor’s interaction with its ligand. Abnormal expression of human epidermal growth factor receptor 2 (HER2) is frequently expressed and observed in a number of primary tumors may contribute to transformation and tumorigenesis. High-level activation of the HER 2 kinase results in the activation of downstream signaling molecules, such as the MAP kinases and the PI 3/ Akt kinases, which both drive proliferation and inhibit apoptosis of the cells.
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