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High heart rate as a potential risk factor for development of cardiovascular diseases in women with rheumatoid arthritis

Author(s): D.S. Novikova | Т.V. Popkova | А.N. Gerasimov | А.V. Volkov | Ye.L. Nasonov

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 8;
Issue: 5;
Start page: 636;
Date: 2012;
Original page

Keywords: rheumatoid arthritis | heart rate | risk factor for development of cardiovascular diseases

Aim. To study relationship between heart rate (HR) and traditional risk factors for cardiovascular diseases (TRF for CVD), subclinical structural and functional changes in the heart and vessels, as well as the activity and severity of rheumatoid inflammation in women with rheumatoid arthritis (RA).Material and methods. A total of 291 female patients less than 60 years of age with a definite diagnosis of RA were examined. The control group consisted of 125 women without rheumatic diseases. Aside from clinical symptoms, activity and severity level of RA, the presence of main TRF for CVD were assessed, 24 h Holter ECG monitoring (24-h ECG), duplex scanning of common carotid arteries, transthoracic echocardiography were performed and the serum levels of inflammatory markers were determined.Results. RA patients compared with the control group women had higher values of minimum (52.3±0.4 vs 47.5±0.4; p
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