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High Serum Levels of Rheumatoid Factor and Anti-Phosphatidylserine Antibody in Patients with Ischemic Heart Disease

Author(s): Abdollah Jafarzadeh | Masoud Poorgholami | Maryam Nemati | Mohammad-Taghi Rezayati

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 1;
Start page: 34;
Date: 2011;
Original page

Keywords: Anti-Nuclear Antibody | Myocardial Infarction | Rheumatoid Factor | Unstable Angina

Background: Immunopathological and inflammatory processes play important roles in the initiation and development of Ischemic Heart Disease (IHD). Objective: The aim of this study was to evaluate the serum levels of several autoantibodies including rheuma-toid factor (RF), anti-nuclear antibodies (ANA), anti-small nuclear ribonucleoprotein (anti-Sm), anti-phosphatidylserine (anti-PS) and anti-cardiolipin (anti-CL) antibodies in patients with IHD. Methods: A total of 120 patients with IHD with acute myocardial infarction (AMI; n=60) or unstable angina (UA; n=60) and 60 sex- and age-matched healthy subjects were enrolled in this study. Serum samples of participants were tested for the ANA, anti-Sm, anti-PS and anti-CL antibodies by ELISA. Serum level of RF was measured by a turbidometric method. Results: The mean serum levels of RF and anti-PS antibodies in AMI group and UA group were significantly higher than those ob-served in the control group (p

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