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High Speed Counter Current Chromatography-A Support free LC Technique

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Author(s): Neha sethi | Ankit anand | Aarti Sharma | Kaushal k Chandrul | Garima Jain | Kona S Srinivasa

Journal: Journal of Pharmacy and Bioallied Sciences
ISSN 0975-7406

Volume: 1;
Issue: 1;
Start page: 14;
Date: 2009;
Original page

Keywords: High speed counter current chromatography | solvent system | centripetal accelerations

ABSTRACT
As separation of components is the major requirement of an analytical chemist, there is always a need of a convenienthigh throughput technique with minimum sample loss, high efficiency, high resolution, ease of samplerecovery without contamination. This leads to the development of High Speed Counter Current Chromatography(HSCCC) in which stationary phase is liquid instead of solid that provides a lot of advantages over other chromatographictechniques. In addition, advanced centrifugal partition technology is used to hold the liquid stationaryphase in column while the liquid mobile phase is pushed through it that provides high yield and purity. This reviewhighlights the major applications of HSCCC that includes extraction of medicinal drugs from plants andpurification and isolation of active material, plant analysis, separation of rare earth elements, preparative-scaleseparations of chiral compounds, analysis of inorganic compounds and elements and drug discovery and drugdevelopment. Separation of dipeptides and proteins, flavonoids, alkaloids, DNP amino acids, indole auxins etc.proves versatile and dynamic nature of the technique.
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