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Highly active antiretroviral therapy: Does it Sound toxic?

Author(s): Khoza-Shangase Katijah

Journal: Journal of Pharmacy and Bioallied Sciences
ISSN 0975-7406

Volume: 3;
Issue: 1;
Start page: 142;
Date: 2011;
Original page

Keywords: Adults | HAART | HIV / AIDS | monitoring | ototoxicity

Objective : The main objective of the current study is to monitor the auditory status in a group of adults with AIDS, receiving Highly Active Antiretroviral Therapy (HAART) (3TC -lamivudine, D4T - stavudine, and efavirenz) in a hospital outpatient clinic in Gauteng. A total sample of 54 adults (between the ages of 18 and 50 years) in the experimental group and 16 in the control group were assessed prospectively following a repeated measures design. All participants were assessed at baseline at three months, and at six months into the treatment. Materials and Methods : The participants underwent case history interviews and medical record reviews, otoscopy, and tympanometry, as well as conventional pure tone audiometry and distortion product otoacoustic emission testing. Both descriptive and inferential statistics were used to analyze the data. Results : On audiological monitoring, statistically significant changes (P
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