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Hippocampal High-Frequency Stimulation Inhibites the Progression of Rapid Kindling-Induced Seizure in Rats

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Author(s): Belen Gori | Magdalena Pereyra | Lucas Toibaro | Carola Brescacin | Gerardo Battaglia | Julieta Pastorino | Ariela Smigliani | Milagros Galardi | Silvia Kochen

Journal: Neuroscience & Medicine
ISSN 2158-2912

Volume: 04;
Issue: 02;
Start page: 71;
Date: 2013;
Original page

Keywords: Hippocampal Rapid Kindling | Epilepsy | Electrical Stimulation | High-Frequency Stimulation | Low-Frequency Stimulation

ABSTRACT
Epilepsy is one of the most common serious neurological disorders. Pharmacoresistant epilepsy patients are poorly controlled or their seizures are refractory to drug treatment. Resective surgery is frequently a promising therapy in this population, however, not all the patients meet the eligibility criteria for the surgical treatment. Deep brain stimulation has been investigated in clinical studies and animal studies as an alternative treatment, but the optimal stimulation parameters remain an issue. The present study was designed to investigate the effect of unilateral high-frequency stimulation (HFS) of hippocampus on seizure development by using the hippocampal rapid kindling method (hRK) in rats, and compared the results with those of low-frequency stimulation previously published by our group. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK; n = 7) received only RK stimulus, while the treated group (HFS-hRK; n = 9) received also HFS (biphasic square wave pulses, 130 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing 78% (p
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