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Histopathologic Effects of Sulfur Dioxide in Mouse Liver Following the Chronic and Acute Exposure

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Author(s): F. Rajaii | A.A. Khaki | A. Khaki | F. Khorshid | N. Borhani | H. Jfraii | H. Haghdust | N. Gheibi

Journal: Journal of Biological Sciences
ISSN 1727-3048

Volume: 8;
Issue: 7;
Start page: 1241;
Date: 2008;
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Keywords: Sulfur dioxide | mouse | liver

ABSTRACT
The present study examined the histopathologic effects of this gas on the mouse liver in acute and chronic exposure. Twenty eight male mice were divided into 4 groups. Group 1 (G1) as control ( not exposed to gas ), group 2 (G2) were exposed to high dose of (100 ppm) and group 3 (G3) and group 4 (G4) were exposed to low dose of sulfur dioxide for 5 min for 1 and 3 weeks (20 ppm). Finally the mice were sacrificed and liver were assessed macroscopically and then the biopsy of the liver were assessed microscopically. The data were analyzed statistically. The results showed that the mean number of kupffer cells in G2, G3 and G4 significantly increased (9 ± 1.0, 10 ± 1.0, 11 ± 1.2 vs 7 ± 1.4 and p
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