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Historical Perspectives in the Development of Antiviral Agents Against Poxviruses

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Author(s): Erik De Clercq

Journal: Viruses
ISSN 1999-4915

Volume: 2;
Issue: 6;
Start page: 1322;
Date: 2010;
Original page

Keywords: thiosemicarbazones | interferon (inducers) | idoxuridine (IDU) | acyclic nucleoside phosphonates | cidofovir | CMX001 (HDP-CDV) | tecovirimat (ST-246) | Gleevec (imatinib)

ABSTRACT
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the chemotherapy or -prophylaxis of poxvirus infections, numerous candidate compounds have been described over the past 50 years. These compounds include interferon and inducers thereof (i.e., polyacrylic acid), 5-substituted 2’-deoxyuridines (i.e., idoxuridine), IMP dehydrogenase inhibitors, S-adenosylhomocysteine hydrolase inhibitors, acyclic nucleoside phosphonates (such as cidofovir) and alkoxyalkyl prodrugs thereof (such as CMX001), viral egress inhibitors (such as tecovirimat), and cellular kinase inhibitors (such as imatinib).
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Tango Jona
Tangokurs Rapperswil-Jona