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HLA-B27 Association with Uveitis in an Asian Indian Population

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Author(s): Mahendra Narin Mishra | Khurshed Minoo Bharucha

Journal: Iranian Journal of Immunology
ISSN 1735-1383

Volume: 8;
Issue: 2;
Start page: 85;
Date: 2011;
Original page

Keywords: Asian | HLA-B27 | Indian | Uveitis

ABSTRACT
Background: Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. Objectives: To establish the frequency of HLA-B27-positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature. Methods: We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required. Results: The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance. Conclusions: HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment.
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