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Hodgkin lymphoma: current conception and unresolved questions

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Author(s): Gurtovoj V.A. | Shponka I.S. | Bilenkij I.V. | Gritsenko P.O.

Journal: Морфологія
ISSN 1997-9665

Volume: 4;
Issue: 2;
Start page: 13;
Date: 2010;
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Keywords: Hodgkin lymphoma | Reed-Sternberg cell | Hodgkin cell

ABSTRACT
Hodgkin lymphoma is the most frequent lymphoproliferative disorder in the Western world. During one and a half century since it was described by Thomas Hodgkin in 1832 wide experience has been accumulated on matching clinical and morphologic manifestations of disease what is shown in a great number of publications. According to World health or-ganization classification of 2008 distinct forms and types of Hodgkin lymphoma were defined in accordance with clinical presentations, pathomorphology and immunophenotype of tumor cells what determine specific treatment. Although clinical manifestations are described well enough, data on morphofunctional features of tumor cells and reactive microenvironment are scarce. Data about the nature of tumor cells are still controversial. Remarkably little attention is paid to the assessment interrelations between morphology, immunophenotype, degree of stability and maturation of diagnostic cells and inflamma-tory background. All these findings may be helpful to clarification of morphogenesis, prognosis and improvement for Hodgkin lymphoma treatment.
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