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Homocysteine and Heart Disease. Does Inadequate Vitamin B and 6 Folate Consumption Increase the Risk for Atherosclerosis?

Author(s): Armagan Hayirli | Fikrullah K?sa | ?zg?r Kaynar

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 4;
Issue: 10;
Start page: 859;
Date: 2005;
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Keywords: Homocysteine | vitamin B 6 | folate | atherosclerosis

Cardiovascular disease (CVD) is the leading cause of mortality in most industrialized countries. Folate and vitamin B have essential role in methionine metabolism. Folate provides a methyl group for the 6 remethylation process of homocysteine (Hcy) back to methione. Vitamin B acts as a cofactor for 6 cystathione-$-synthase, which catalyzes the conversion of tetrahydrofolate to methylene-tetrahydrofolate (CH -THF). Recent studies have shown that hyperhomocysteinemia is an independent risk factor for CVD. 2 Deficiency of folate and vitamin B results in increase in Hcy concentration and decrease in intermediary 6 product, S-adenosylmethione (SAM). This compound is the principal methylation agent and plays role in nucleic acid and protein synthesis and integration and proper function of cells. Homocysteine alters the surface properties of endothelial cells. Reduced form of homocysteine undergoes oxidation process. End products of this process are hydrogen peroxide, superoxide and hydroxyl radicals. These products interfere with vascular function. The objective of this study was to present relevant studies concerning the metabolism of Hcy, its role in development of atherosclerosis and its relation to vitamin B and folate status.
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