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Homology modeling of dihydroorotase in Plasmodium falciparum

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Author(s): Rajesh Sharma*, Anupama Parate and Abhishek Tiwari

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 3096;
Date: 2011;
Original page

Keywords: Homology Modeling | Plasmodium falciparum | Dihydroorotase

ABSTRACT
Nucleic acid metabolism pathways differ between P. falciparum and the human host. Plasmodia synthesize purines and pyrimidines by salvage and de novobiosynthetic pathways, respectively, while mammalian cells synthesize purines de novo and either salvage or synthesize pyrimidine by a de novo pathway. The twopathways involve a range of essential enzymes that can be targeted for therapeutic intervention[7]. Malaria parasites derive their pyrimidine nucleotides througha de novo pathway. The salvage enzymes (uridine kinase and thymidine kinase) are absent in the parasite. The de novo enzymes are carbamoyl phosphate synthase,aspartate transcarbamylase, dihydroorotase, dihydroorotate dehydrogenase (PfDHODH), orotate phosphoribosyl transferase and orotidine 5-phosphate decarboxylase[8]. The three-dimensional structure of a protein provides important information for understanding its biochemical function and interaction properties inmolecular detail.
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