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How does viral DNA find the nucleus of an infected cell?

Author(s): Herbert Widulle

Journal: GMS Krankenhaushygiene Interdisziplinär
ISSN 1863-5245

Volume: 7;
Issue: 1;
Start page: Doc01 ;
Date: 2012;
Original page

Keywords: migration | virus genome | cell nucleus | mechanism | force | gradient | metabolism

If all locations of a living cell would have the same chemical potential, most viral infections of a cell should be abortive, even after the a penetration of the cell wall by the viral DNA-polymer or viral RNA-polymer occurred. This is obviously not the case. Therefore, there must be a mechanism which transports a viral DNA-polymer from the cell wall to the nucleus and not to any other location. A possible mechanism is proposed which is in accordance with biophysical chemistry. The presented description of the mechanism uses non equilibrium thermodynamics to find a simple solution for the problem.
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