Academic Journals Database
Disseminating quality controlled scientific knowledge

HTLV-1 and Innate Immunity

ADD TO MY LIST
 
Author(s): Chloé Journo | Renaud Mahieux

Journal: Viruses
ISSN 1999-4915

Volume: 3;
Issue: 8;
Start page: 1374;
Date: 2011;
Original page

Keywords: HTLV-1 | innate immunity | interferon | monocytes | dendritic cells | natural killer cells

ABSTRACT
Innate immunity plays a critical role in the host response to a viral infection. The innate response has two main functions. First, it triggers effector mechanisms that restrict the infection. Second, it primes development of the adaptive response, which completes the elimination of the pathogen or of infected cells. In vivo, HTLV-1 infects T lymphocytes that participate in adaptive immunity but also monocytes and dendritic cells that are major players in innate immunity. Herein, we will review the interplay between HTLV-1 and innate immunity. Particular emphasis is put on HTLV-1-induced alteration of type-I interferon (IFN-I) function. In vitro, the viral Tax protein plays a significant role in the alteration of IFN synthesis and signaling. Despite this, IFN-I/AZT treatment of Adult T‑cell Leukemia/Lymphoma (ATLL) patients leads to complete remission. We will discuss a model in which exogenous IFN-I could act both on the microenvironment of the T-cells to protect them from infection, and also on infected cells when combined with other drugs that lead to Tax down-regulation/degradation.
Affiliate Program      Why do you need a reservation system?