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Human Leukocyte Antigen Profile of Two Ethnic Groups in Southeast of Iran

Author(s): Hossein Ali Khazaei | Nima Rezaei | Asghar Aghamohammadi | Ali Akbar Amirzargar | Khadidjeh Mollaei Ghasemi | Ibrahim MiriMoghaddam | Behrouz Nikbin

Journal: Iranian Journal Of Allergy, Asthma and Immunology
ISSN 1735-1502

Volume: 6;
Issue: 4;
Start page: 223;
Date: 2007;
Original page

Keywords: Anthropology | Human Leukocyte Antigen | Human Populations | Iran

This study was performed to determine the genetic diversity of HLA class I and II alleles among two ethnic groups in Southeastern Iran. HLA profiles were determined in 71 Iranian populations (41 Zaboli and 30 Baloch). The frequencies of HLA-A02 (p=0.017), -Cw4 (p=0.003), and -DR8 (p=0.025) in the Zaboli populations were significantly higher than that in Baloch ethnic group. In contrast, the frequency of HLA-A23 allele was more frequent in Baloch than Zaboli (p=0.020). This report represents an important resource for investigators in the fields of transplantation immunology and population genetics from widely dispersed areas of Iran.

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