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Human Metapneumovirus and Community-Acquired Pneumonia in Children

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Author(s): Pen-Yi Lin | Tzou-Yien Lin | Yhu-Chering Huang | Kuo-Chien Tsao | Ya-Ling Huang

Journal: Chang Gung Medical Journal
ISSN 2072-0939

Volume: 28;
Issue: 10;
Start page: 683;
Date: 2005;
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Keywords: human metapneumovirus | community-acquired pneumonia.

ABSTRACT
Background: Human metapneumovirus (hMPV) was first recognized in the Netherlands in2001 from nasopharyngeal aspirate samples and was associated with respiratorytract illness in the pediatric population. This was the first report ofmetapneumovirus infections in community-acquired pneumonia in Taiwan.Methods: A total of 116 nasopharyngeal aspirate samples from patients with community-acquired pneumonia was examined by reverse transcriptase polymerasechain reaction (RT-PCR). Other respiratory tract pathogens were also examined.The clinical characteristics and laboratory data were analyzed.Results: Out of the 116 patients, potential causative agents were detected in 95(81.9%) patients. A total of six human metapneumovirus RT-PCR positivesamples was identified. All of these had evidence of coinfection with bacteria(3 Streptococcus pneumoniae, 2 Mycoplasma pneumoniae, 1 Chlamydiapneumoniae). Coinfection with other respiratory viruses was also observed intwo cases (1 influenza A, 1 parainfluenza type 3). The age distribution wasseven to 11 years except for one patient who was two years of age (Case 1).The most common clinical findings were fever (6/6, 100%), cough(6/6,100%), rhinorrhea (5/6, 83.3%), rales (5/6, 83.3%) and wheezing (1/6,16.7%). Chest radiographs revealed four with lobar patches and two withinterstitial infiltrations. The mean duration of hospital stay was 5.5 ± 2.8days. All patients made a complete recovery.Conclusions: hMPV was identified in 5.2% of patients with community-acquired pneumonia.Our data showed a high rate of coinfection with hMPV in communityacquiredpneumonia. Human metapneumovirus infection, like other respiratoryviruses, may predispose to secondary bacterial pneumonia.
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