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Human Papillomavirus Typing in HIV-Positive Women

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Author(s): Meera Hameed | Helen Fernandes | Joan Skurnick | Dorothy Moore | Patricia Kloser | Debra Heller

Journal: Infectious Diseases in Obstetrics & Gynecology
ISSN 1064-7449

Volume: 9;
Issue: 2;
Start page: 89;
Date: 2001;
Original page

ABSTRACT
Objective: Human papillomavirus (HPV) is the major cause of cervical carcinoma and cervical intraepithelial neoplasia worldwide. Certain HPV types have a strong association with and probably a causative role in the pathogenesis of premalignant cervical lesions. Epidemiologic studies in women infected by the human immunodeficiency virus (HIV) have shown an increased incidence of squamous intraepithelial lesions (SILs), whichwere predominantly high-grade. Six to 30 per cent of women diagnosed with atypical squamous cells of undetermined significance (ASCUS) on a Papanicolaou (Pap) smear harbor SIL in normal screening populations. This study was undertaken to determine the presence of low- and high-risk HPV types in women infected by HIV and to correlate the results to those of the Pap smear.
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