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Hybrid organic/inorganic nanomaterial for controlled cephalosporins release

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Author(s): Dan Eduard Mihaiescu | Alexandru Mihai Grumezescu | Diana Elena Mogosanu | Vanessa Traistaru | Paul Catalin Balaure | Alice Buteica

Journal: Biointerface Research in Applied Chemistry
ISSN 2069-5837

Volume: 1;
Issue: 2;
Start page: 41;
Date: 2011;
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Keywords: cephalosporins | hybrid organic/inorganic | controlled release | ferrofluid | nanomaterial

ABSTRACT
The cephalosporins release behavior from hybrid organic/inorganic nanomaterial has been evaluated. Sol-gel method was used for Fe3O4 nanoparticles synthesis Fe3O4 / oleic acid – core/shell has been prepared under microwave conditions for 10 minutes. The dimensions of Fe3O4/oleic acid nanoparticles were in the 5-20 nm range and they were previously characterized by High Resolution Transmission Electron Microscopy. After 24 hours at 105 oC, hybrid nanomaterial was dispersed in CHCl3, and then added cephalosporins. The cephalosporins deposition concentration on magnetic nanofluid was 0.3 %. The cephalosporin controlled release dynamics from the core/shell was studied by conductometry method and UV-VIS spectrometry. The analytical data confirm a larger retention in the case of the nanostructured support adsorption of all the active compounds. In all cases, at high times - over 4000 seconds the cephalosporins are far off the solubility threshold, which demonstrates that the adsorption in a hybrid nanostructurated material is a viable version for a slow release of active compounds in the dispersion medium.
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Tango Jona
Tangokurs Rapperswil-Jona