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Hyperglycemic-dependent LXR-alpha Gene Regulation within Blood Mononuclear Cells of CHD Patients

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Author(s): Deepak Kaul

Journal: Journal of Clinical & Experimental Cardiology
ISSN 2155-9880

Volume: 2;
Issue: 1;
Date: 2011;
Original page

Keywords: Glucose | Fructose | LXR-alpha | 22(R) OH cholesterol

ABSTRACT
Keeping in view the fact that Liver X receptor alpha (LXR-α) is a glucose sensor, the present study was designed to explore the dose dependent synergistic action of glucose and fructose on the regulation of LXR- alpha transcriptional activity in peripheral blood mononuclear cellular model. Gene expression study revealed that under normal physiological range of glucose and fructose, LXR-alpha is able to modulate its effector genes whereas at high concentration of glucose and fructose the transcriptional activity of LXR-alpha becomes redundant. The redundant activity of LXR-alpha was further precipitated by the increased intracellular cholesterol as well as foam cell formation in response to high dose of glucose and fructose. Further, LXR-alpha ligand was able to restore glucose induced impaired transcriptional activity of LXR-alpha. Thus use of LXR-alpha ligands may be beneficial for the treatment of diabetes induced Coronary Artery Disease.
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