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HYPOGLYCEMIC ACTIVITY OF PASSIFLORA EDULIS SIMS LEAF EXTRACT IN WISTAR ALBINO RATS

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Author(s): Kanakasabapathi Devaki | Uthamaraj Beulah | Govindraj Akila | Martin Sunitha | Velliyur Kanniappan Gopalakrishnan

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 170;
Date: 2011;
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Keywords: Passiflora edulis | Hypoglycemia | Alloxan mono hydrate | GTT

ABSTRACT
The traditional medicinal plant P.edulis was tested for its hypoglycemic effect in Wistar albino rats. The oral glucose tolerance test was performed in overnight fasted normal as well as in alloxan induced diabetic rats (150 mg/kg, of alloxan, i.p.) with the administration of 100,200,300,400 mg/kg of b.wt of P.edulis. The blood sample withdrawn at 0, 60, 120, 180 min of glucose administration from the retro orbital sinus by capillary puncture indicated the hypoglycemic nature of the P.edulis leaf extract and identified the most effective dose as 200mg/kg b.wt.
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