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Hypoglycemic of Cajanus scarabaeoides in glucose overloaded and streptozotocin-induced diabetic rats

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Author(s): Suman Pattanayak, Siva Shankar Nayak, Durgaprasad Panda and Vikas Shende

Journal: Bangladesh Journal of Pharmacology
ISSN 1991-007X

Volume: 4;
Issue: 2;
Start page: 131;
Date: 2009;
Original page

Keywords: Cajanus scarabaeoides | Diabetes mellitus | Hypoglycemic | Streptozotocin

ABSTRACT
In light of traditional claim of Cajanus scarabaeoides (L) in the treatment of diabetes, we studied the effects of different solvent extracts in normal, glucose over loaded normal rats and streptozotocin-induced diabetic rats. The methanolic extract (500 mg/kg orally) was produce significantly reduce blood glucose level at normal, glucose over loaded normal rats, and streptozotocin-induced diabetic rats after 15 days treatment; whereas petroleum ether and chloroform extract (500 mg/kg orally) did not exhibit any significant effect on three groups of rats. Histopathology studies on pancreas of streptozotocin-induced diabetic rats shows inflammatory changes in pancreatic islets, results from selective destroy of insulin producing β-cells. These changes are inhibited by C. scarabaeoides methanolic extract and gliclazide. The antidiabetic activity of methanolic extract may be due to the presence of flavonoids.
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