Academic Journals Database
Disseminating quality controlled scientific knowledge

HYPOLIPEDEMIC EFFECT OF EMBLICA OFFICINALIS ON HISTOPATHOLOGICAL STUDY AND DNA FRAGMENTATION ANALYSIS IN EXPERIMENTALLY INDUCED HYPERCHOLESTEREMIC RATS

ADD TO MY LIST
 
Author(s): Dr C. SELVA KUMAR | R. KALAIVANI

Journal: International Journal of Pharma Sciences and Research
ISSN 0975-9492

Volume: 2;
Issue: 8;
Start page: 168;
Date: 2011;
VIEW PDF   PDF DOWNLOAD PDF   Download PDF Original page

Keywords: Emblica officinalis | Cholesterol | DNA fragmentation.

ABSTRACT
Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Emblica officinalis on histopathological study and DNA fragmentation analysis in experimentally induced hypercholesteremic rats. Four groups of rats were employed namely control, hypercholesterolemia rats (4% Cholesterol+1% cholic acid), Emblica officinalis treatment in hypercholesteremic rats and Emblica officinalis alone treated rats. Results of DNA fragmentation was found to be greater in High cholesterol diet fed groups. Lesser fragmentation was found in high cholesterol diet + Emblica officinalis treated group when compared to the high cholesterol diet group. Emblica officinalis alone treated group is comparably similar to that of normal group (lesser fragmentation). Histopathological study of thoracic aorta of Emblica officinalis treated group shows decrease in atherogenicity compared to untreated high cholesterol diet fed rats .The data demonstrated that Emblica officinalis formulation was associated with hypolipidemic effects on the experimentally induced hypercholesteremic rats.
Why do you need a reservation system?      Affiliate Program