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Hypolipidemic Activity of Protocatechuic Acid in Atherogenic Diet Induced Hyperlipidemic Rats

Author(s): Borate AR | Suralkar AA | Deshpande AD | Malusare PV | Bangale PA

Journal: International Journals For Pharmaceutical Research Scholars
ISSN 2277-7873

Volume: 1;
Issue: 1;
Start page: 22;
Date: 2012;
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Keywords: Atherogenic diet | Protocatechuic acid | Cholesterol | Hyperlipidemia | Hypolipidemic activity

Hyperlipidemia is an abnormally high level of fatty substances called lipids, largely cholesterol andtriglycerides, in the blood. The present study was designed to investigate the hypolipidemic effects ofProtocatechuic acid in atherogenic diet induced hyperlipidemia. In atherogenic diet inducedhyperlipidemic model, the rats receiving treatment of Protocatechuic acid at the dose of 25 and 50mg/kg showed significant reduction in total cholesterol, triglyceride, total protein and elevation in highdensity lipoprotein cholesterol. Hence by considering the effects observed in this model, it has beensuggested that Protocatechuic acid was found to possess significant hypolipidemic activity, this may bedue to its effect on increasing the metabolism of the cholesterol by activating lipoprotein lipase or byincreasing reverse cholesterol transport.
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