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Icariin Changes ANGPTL3 Expression and LPL Activity to Improve Meat Quality in Swine

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Author(s): Hong-Bo Xiao | Ji-Ying Wang | Zhi-Liang Sun

Journal: Journal of Animal and Veterinary Advances
ISSN 1680-5593

Volume: 11;
Issue: 9;
Start page: 1450;
Date: 2012;
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Keywords: Icariin | meat quality | angiopoietin-like protein 3 | lipoprotein lipase | swine

ABSTRACT
Excessive cholesterol and fatty acids in the diet can lead to cardiovascular disease. Recent studies have reported that elevated Angiopoietin-Like Protein 3 (ANGPTL3) expression contributes to dyslipidemia. The aim of the study was to examine the beneficial effect of icariin, an active flavonoid glucoside, on meat quality in swines and the mechanisms involved. About 36 Duroc x Landrace x Yorkshire swines with an initial average body weight 65 kg were randomly divided into 3 groups: control swines group, two groups of icariin-treated swines (0.1 or 0.3%). About 42 days after, icariin (0.1 or 0.3%) treatment significantly decreased fat meat percentage, drip loss rate, plasma and hepatic total cholesterol levels, plasma and hepatic triglyceride concentrations, expression of ANGPTL3 mRNA and increased meat color, lean meat percentage, plasma high-density lipoprotein cholesterol level, activity of Lipoprotein Lipase (LPL). The present results suggest that icariin changes ANGPTL3 expression and LPL activity to improve meat quality in swine.
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