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Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria

Author(s): Anahit Penesyan | Jan Tebben | Matthew Lee | Torsten Thomas | Staffan Kjelleberg | Tilmann Harder | Suhelen Egan

Journal: Marine Drugs
ISSN 1660-3397

Volume: 9;
Issue: 8;
Start page: 1391;
Date: 2011;
Original page

Keywords: marine bacteria | bioactive | antimicrobial | symbiosis | tropodithietic acid

Surface-associated marine bacteria often produce secondary metabolites with antagonistic activities. In this study, tropodithietic acid (TDA) was identified to be responsible for the antibacterial activity of the marine epiphytic bacterium Pseudovibrio sp. D323 and related strains. Phenol was also produced by these bacteria but was not directly related to the antibacterial activity. TDA was shown to effectively inhibit a range of marine bacteria from various phylogenetic groups. However TDA-producers themselves were resistant and are likely to possess resistance mechanism preventing autoinhibition. We propose that TDA in isolate D323 and related eukaryote-associated bacteria plays a role in defending the host organism against unwanted microbial colonisation and, possibly, bacterial pathogens.

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