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Identification of Ceftiofur Oxidation Products by High-Performance Liquid Chromatography/Electrospray Ionization/Tandem Mass Spectrometry

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Author(s): Young-Hee Lim | Deok-Hie Park | Yeu Young Youn | Kyoung Hoon Kim | Hye-Sung Cho

Journal: Mass Spectrometry Letters
ISSN 2233-4203

Volume: 2;
Issue: 1;
Start page: 16;
Date: 2011;
Original page

Keywords: Ceftiofur | Oxidation | ESI | Density-functional Calculation | Hydrogen Bonding

ABSTRACT
Oxidation products of ceftiofur were formed in hydrogen peroxide solution. The structures of the ceftiofur oxidationproducts were characterized by high-performance liquid chromatography/electrospray ionization/tandem mass spectrometry(HPLC/ESI/MS/MS). The products were identified as compounds oxidized at the sulfur of a cephem ring. For further analysis,experiments were performed using O18-labeled hydrogen peroxide. In addition, density-functional calculations were carried out forsix possible oxidation products to support the experimental results.
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