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Identification of N-acetylglucosaminyltranferase-IV as a modifier of Epstein-Barr virus BZLF1 activity

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Author(s): Amy L. Adamson

Journal: Open Journal of Genetics
ISSN 2162-4453

Volume: 03;
Issue: 01;
Start page: 1;
Date: 2013;
Original page

Keywords: Epstein-Barr Virus | BZLF1 | Drosophila | CG9384 | Gnt-IVb

ABSTRACT
Epstein-Barr virus is a prevalent human herpesvirus, with about 95% of the world’s adult population positive for anti-EBV antigen antibodies. After the initial infection and production of new virus particles, the virus may enter a latent state within a subset of cells, and therefore can remain within the host indefinitely. Epstein-Barr virus contributes to a variety of diseases, including many types of cancers. We have created a model system in Drosophila melanogaster to study the effect of expression of the Epstein-Barr virus protein BZLF1, and to identify cellular proteins that mediate BZLF1 activity. Here we present the results of a genetic screen that determined that the Drosophila melanogaster CG9384 gene (an N-acetylglucosaminyl-transferase) is a significant modulator of BZLF1 activity and EBV early lytic replication. 

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Tangokurs Rapperswil-Jona

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