Academic Journals Database
Disseminating quality controlled scientific knowledge

IDENTIFICATION OF T-CELL EPITOPE FOR PROTECTIVE ANTIGEN AND LETHAL FACTOR OF Bacillus anthracis - AN IMMUNOINFORMATICS APPROACH

ADD TO MY LIST
 
Author(s): Anuraj Nayarisseri, Mukesh Yadav, Sheaza Ahmed, Jyoti Sahu, Priyanka Gupta, Rachna Chourasia and Deepti Mittal

Journal: International Journal of Drug Discovery
ISSN 0975-4423

Volume: 4;
Issue: 1;
Start page: 137;
Date: 2012;
Original page

Keywords: T-Cell Epitope | Bacillus anthracis | Protective Antigen | Lethal factor.

ABSTRACT
Anthrax is an infectious disease caused by spores of the bacterium, Bacillus anthracis. The B. anthracis spores are highly resistant to inactivation and may be present in the soil, for example, for decades, occasionally infecting grazing animals that ingest the spores. Goats, sheep and cattle are examples of animals that may become infected. Human infection may occur by three routes of exposure to anthrax spores: cutaneous (through the skin), gastrointestinal (by ingestion) and pulmonary (inhalation). A major factor in the virulence of Bacillus anthracis is its secretion of three binary toxins, protective antigen, lethal toxin and edema toxin. These toxins possess a common cell receptor-binding (B) component but have distinct biochemically active (A) components. In traditional vaccine approaches made researchers to produce vaccine very easy. The current approach was based upon the insilico identification of T-Cell Epitopes and its binding affinity with MHC Class II. The T-Cell Epitope was identified using the HLAPred which identifies the peptide class that binds with both MHC Class I and II. Further the Epitope was analyzed for peptide characteristics such as antigenic nature, lipophilicity and solvent assessable. Out of all peptides the peptide which shows all the character for further analyzed for protein peptide interaction to find the high affinity binding peptide with low energy.

Tango Jona
Tangokurs Rapperswil-Jona

     Save time & money - Smart Internet Solutions